hydroxycitric acid hca

Hydroxycitric Acid Clinical Studies

Do Hydroxycitric Acid (HCA / Garcinia Cambogia) can lose weight efficiently?

The conversion of carbohydrate to fat requires that pyruvate is oxidized to acetyl-CoA. This oxidative process occurs within the mitochondria. However, fatty acid synthesis occurs predominately in the cytosol.

Therefore, the acetyl group, which is the intermediate substrate for fatty acid synthesis… must be transported from inside the mitochondria to the cytosol before it can be incorporated into fatty acids.

Once outside, an enzyme, ATP­ citrate lyase, catalyzes the reaction, which cleaves citrate into acetyl-CoA and oxaloacetate. The acetyl group then enters the biosynthetic pathway of fatty acid synthesis.

Hydroxycitric acid (HCA) is an inhibitor of the enzyme ATP-citrate lyase. Therefore, it prevents the conversion of carbohydrates into fatty acids. That is by preventing the breakdown of the citrate in the cytosol.

Many products are currently on the market that contains HCA among other ingredients. HCA is obtained from the extracts of the herbs Garcinia Cambogia and Garcinia Indica, both native to Southeast Asian.

Animal studies have shown HCA to be effective in reducing fatty acid synthesis. However, there is a lack of well-controlled human studies.

Garcinia Cambogia

Animal Studies

Several well-controlled animal studies have investigated HCAs effect on fatty acid synthesis.

In general, they have all shown that HCA-administered orally and intravenously. It can be used by intraperitoneal injection-inhibits fatty acid biosynthesis in the liver and adipose tissue.

The degree of inhibition depends on the dosage and can range from 20% to 80%. The decrease in fatty acid biosynthesis resulted in significant reductions in epididymal fat stores and total body fat.

Another interesting aspect of HCA was the reduction in food intake during HCA administration.

Curiously, the reduction in food intake could not completely account for the decrease in body weight. Also, cholesterol and triglyceride levels were lower following HCA administration.

Human Studies on Hydroxycitric Acid (HCA)

As mentioned above, well-controlled human studies investigating the fat-loss potential of HCA are lacking.

Most of the studies have been investigating the HCAs effect on body composition. That is by using other ingredients, which could also be active ingredients.

Of the seven studies reviewed by Heymsfield et al. only two have been published in peer-reviewed journals. Heymsfield and coworkers are the only ones to use HCA by itself.

The other studies have appeared only in abstract form. It has investigated HCA in combination with other components. This may also be considered to promote fat loss.

All but one of the studies have reported… If the HCA, combined with other fat-loss supplements! It can produce significantly greater losses in fat than a placebo.

The single study to investigate HCA by itself as the active ingredient reported… HCA failed to produce weight loss and fat mass loss beyond that observed with a placebo in overweight men and women.

Based on the limited research, HCA could promote fat loss, but only when used in combination with other components of fat loss supplements.

Further research needs to investigate HCA supplementation alone and when used in combination with other ingredients.

The discrepancies between the animal and human studies are interesting. But, as we are learning from leptin research, the regulation of fat metabolism in rats appears to be much different than that in humans.

Read also: how hormonal imbalance can affect weight loss

Safety and Toxicity

Neither animal nor human studies have reported any treatment-related adverse events. A few animal studies have included tests specifically to look at liver function.

The human studies have simply used an adverse incident reporting form. It has reported that adverse events were not significantly different between the treatment group and placebo group.

Summary
Reviewed Item
Hydroxycitric Acid Clinical Studies
Author Rating
51star1star1star1star1star

Related posts

  • vitamins minerals benefits
    Benefits of Vitamin and Minerals to the Body

    Vitamins and minerals are vital to life and to the optimum functioning of our bodies. We need the correct nutrients to fight illnesses, boost our immune system, slow aging...

  • gynecomastia pills
    Best Gynecomastia Pills Review

    Top-Rated Gynecomastia Pills Of The Year Knowing which is the best gynecomastia pills is an impossible task, especially since choosing the wrong one can impact your overall health and well-being....

  • Cellucor C4 Review – Do C4 Pre-Workout Supplements Really Work?

    Rumors say C4 is the best pre-workout supplement. Is that true? Find the real answer in the following Cellucor C4 review. When you’re building muscle mass, you need to...

  • endomorph diet exercise plan
    Endomorph Diet and Exercise Plan

    Those classified into the endomorphic body type are easily recognized by their large amount of fat accumulation. This abundance of adipose tissue does not allow for much in the...

  • vitamins sports supplements
    Role of Vitamins in Sports Supplements

    You might be wondering, what are the best vitamins to take for athletes? Some people try to enhance performance with antioxidant supplements. There are usually 3 types of vitamins mixed, such...