enterostatin

Enterostatin Effects for Reducing Fat Intake

A peptide that acts similar to Cyclo (His-Pro) is Enterostatin or APGPR.

Enterostatin is a pentapeptide that has been shown to be selective in inhibiting fat intake.

It is formed following the cleavage of the enzyme procolipase by trypsin in the gastric juice of the intestinal lumen.

Procolipase is an enzyme essential for fat digestion. Following the cleavage of procolipase, enterostatin and colipase are produced.

Colipase is an obligatory cofactor for pancreatic lipase digestion of fat.

It appears to act as a fat satiety factor that is believed to inhibit fat intake via receptors in the gut and brain. However, there may be a limitation to its use.

Most of the research so far has investigated exogenous process in animals! Only one study has administered it to humans.

Therefore, it is difficult to know whether to function effectively in humans.

Enterostatin Studies on Animal

Several studies have shown that peripheral or central enterostatin inhibits food fat intake.

Two mechanisms appear to be of action, depending on the location of administration. Peripherally, enterostatin reduces gastric emptying.

The slow rate of gastric emptying could result in greater gastric distension increasing satiety. Furthermore, it may also interact with gut receptors, regulating motility and satiety.

Centrally, it appears to interact with the opioid pathway. This process modulates the selection and consumption of high-fat diets.

Enterostatin does not delay the onset of feeding but appears to shorten the time spent eating.

An interesting aspect in rats! It appears to reduce fat intake only in animals that have been adapted to diets which are high in fat before testing.

In animals that have been adapted to a standard diet or a high-carbohydrate diet! There appear to be no effects in reducing fat intake.

enterostatin reducing fat intake

Human Studies

Enterostatin response to feeding in humans is similar to that in rats. Serum enterostatin increased in response to a large meal. However, some sensitivity and detection problems have been associated with the immunoreactive test to measure them.

Giving to obese men has no significant effect on eating behavior. However, other researchers have reported, this intravenous administration is not the most efficient method.

Animal studies have reported that intravenous administration results in a prolonged response delay. No other studies have been published which have orally administered enterostatin to humans.

Safety and Toxicity

Animal studies have not reported any adverse reactions. These associated with enterostatin administration, either peripherally or centrally. The only human study reported no adverse reactions.

The only potential problem that could be found relates to the dosage.

The dose-response is U-shaped. This exhibiting an inhibition of fat intake at lower doses, but stimulation of food intake at higher doses.

Because of this dose-response curve, there could be a range of functional dosages which could depend on a number of physiological factors.

Summary
Reviewed Item
Enterostatin Effects
Author Rating
51star1star1star1star1star

Related posts

  • dhea supplementation
    DHEA Supplementation – Taking DHEA To Lose Weight, Does it work?

    Can DHEA supplementation help with weight loss effectively? Dehydroepiandrosterone (DHEA) is a precursor to testosterone. In the biochemical pathway to testosterone, it lies two steps away. DHEA was one...

  • ectomorphic body type
    Ectomorphic Body Type

    Most notable for their high metabolism and small frame the Ectomorph does not accumulate fat very easily. That said they also do not easily gain muscle mass either so...

  • cardio while bulking
    Cardio While Bulking, Should You Do it?

    Perform cardio while bulking? Well, some folk says… “You’re stupid if you do cardio exercise while bulking!”. Other says “It’s actually beneficial for muscle building…”. It’s a widely debated activity...

  • isagenix review
    Isagenix Weight Loss Review, Does It Really Work?

    Is There an Isagenix Scam Going On? My Opinion and Isagenix Review… You probably found this site while doing a web search for ‘Isagenix scam’, ‘Isagenix review’, or ‘Isagenix...

  • polyphenol antioxidant
    Polyphenol and Compounds contain Polyphenolic Derivatives

    Antioxidant supplementation with polyphenol extract blends Phytochemicals, polyphenol, and their derivatives including the flavonoids, tannins, and catechins! They are molecules derived from plants that have potential benefit for human...